Ongoing Cardiometabolic Initiatives

The projects featured below are designed to improve cardiometabolic care either by demonstrating effectiveness or scaling to other
health systems.

To learn more, watch our American Journal of Managed Care (AJMC) roundtable discussion below, in which experts discuss real-world learnings and share best practices on how to start, sustain, and scale interventions for cardiovascular care.

Transforming the Management of Cardiovascular Disease at Scale:
Implementation Science in Practice

An American Journal of Managed Care Roundtable (Sponsored by Amgen)

Leveraging Implementation Science: Impactful Initiatives

Experts discuss implementation of science-based LATTICE™ initiatives, including LOGAN-CV, Cardiometabolic Center Alliance, and PROMPT-LIPID, and outline the benefits of leveraging EHR systems as a support tool for launching and scaling initiatives.

Securing Stakeholder Support for Implementation Science Initiatives

Experts provide strategies and best practices for engaging important stakeholders within health systems for buy-in on implementation science initiatives.

Operationalizing Implementation Science Initiatives

Our panel discusses methods to ensure the success of implementation science initiatives, including a strong system of measurement, a strategic communication plan, and preparedness to address challenges.

Scaling and Dissemination of Implementation Science Initiatives

Implementation science experts explain approaches for scaling initiatives to more than one health system and discuss the future of LATTICE™ Consortium.

Introduction to Implementation Science and LATTICE™ Consortium

Thought leaders explain implementation science, explain how it can be applied to day-to-day clinical practice, and provide an overview of LATTICE™ Consortium.

Projects and Publications

For more information about the projects, please reach out to the corresponding author in the publication or to the project contact.

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HEARTWISE-ASCVD

Implementation of opportunistic AI-based coronary artery calcium screening
Learn more about this initiative

Barriers the Project Aims to Address

Lack of Quality Metrics, Lack of Standardized Metrics, Clinical Inertia, Clinical Awareness, Poor ASCVD Awareness/Unintentional nonadherence

Aim

Evaluate how opportunistic AI-based coronary artery calcium (CAC) screening plus notification affects lipid-lowering therapy (LLT) and LDL-C levels in patients with ASCVD or CAC scores > 100, while assessing its impact on downstream healthcare utilization patterns*

Strategies

Quality Initiatives/Financial Incentives 

Monitor and address care gaps 

IT EHR Strategies

Engage patients

Audience Engaged

Health system

HCP

Patient

Project Contact:

Please reach out to
frodriguez@stanford.edu and

ats114@standford.edu for additional project information.
*This is a collaborative study sponsored by Amgen.
Projects and Publications

For more information about this project, Please reach out to the coresponding author in the publication or to the project contact
Learn more about this initiative

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Barriers the Project Aims to Address

Lack of quality metrics, guideline changes and inconsistencies, lack of standardized metrics, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

Aim

Leverage computerized decision support tools to promote guideline-concordant, high-value, quality care for patients with very high-risk ASCVD*

Strategies

Prompts/reminders

Education

Audience Engaged

HCP

Health system

Project Contact:

Please reach out to ralph.rielloiii@yale.edu

for additional project information.

PROMPT-Lipid

Shah, Nimish N et al. “Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID).” American Heart Journal vol. 253 (2022): 76-85. doi:10.1016/j.ahj.2022.07.002

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*PROMPT-LIPID Multicenter Registry Study is an Amgen-sponsored study that takes the learnings from an Amgen investigator-initiated study and studies how to

leverage these learnings at multiple sites.
PROMPT-Lipid Multicenter Registry Study

Pragmatic trial of messaging to providers about treatment of HyperLIPIDemia
Learn more about this initiative

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Barriers the Project Aims to Address

Lack of quality metrics, guideline changes and inconsistencies, lack of standardized metrics, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

Aim

Leverage computerized decision support tools to promote guideline-concordant, high-value, quality care for patients with very high-risk ASCVD*

Strategies

Prompts/reminders

Education

Audience Engaged

HCP

Health system

Project Contact:

Please reach out to ralph.rielloiii@yale.edu

for additional project information.

PROMPT-Lipid

Shah, Nimish N et al. “Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID).” American Heart Journal vol. 253 (2022): 76-85. doi:10.1016/j.ahj.2022.07.002

Read publication
*PROMPT-LIPID Multicenter Registry Study is an Amgen-sponsored study that takes the learnings from an Amgen investigator-initiated study and studies how to leverage these learnings at multiple sites.
Corrie Lipids

Examining real-world implementation of the patient-centered Corrie Lipids program
Learn more about this initiative

Barriers the Project Aims to Address

Healthcare disparities, patient lack of knowledge of the importance of LLTs, poor ASCVD awareness/unintentional nonadherence, clinician knowledge gap, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

Aim

Implement a scalable and evidence-based Corrie Lipids Program (Corrie Health, Inc) to increase low-density lipoprotein cholesterol (LDL-C) awareness, treatment, and achievement of guideline-directed management

Examine real-world implementation of the patient-centered Corrie Lipids Program guided by the implementation science framework, RE-AIM (reach, effectiveness, adoption, implementation, maintenance)^†

Strategies

Patient-facing app

Clinician-focused education

Virtual coaching

Guideline-based lipid testing

Audience Engaged

Health system

PCPs

Patient

Project Contact:

Please reach out to
fmarvel1@jhmi.edu

for additional project information.
^†This is a collaborative study sponsored by Amgen.

LLTs = lipid-lowering therapies.
CHA Test to Treat

Implementation of a large-scale program to identify interventions that could impact patient treatment and adherence to guideline-recommended lipid-lowering therapies
Learn more about this initiative

Barriers the Project Aims to Address

Lack of quality metrics, lack of internal support, guidelines changes and inconsistencies, clinician knowledge gap, clinical inertia, clinical awareness, continuity of care, patient lack of knowledge of the importance of LLTs, suboptimal guideline-directed medical therapy, and poor ASCVD awareness/unintentional nonadherence

Aim

Improve LDL-C testing and treatment planning prior to ASCVD hospital discharge and minimizing loss to follow up prior to 6 months^‡

Project Contact:

Please reach out to lauren.w.cohen@duke.edu

for additional project information.

Strategies

Prompts/reminders

Education

Navigators/care team model

Audience Engaged

Patient

HCP

Health system

Strategies

Prompts/reminders

Education

Navigators/care team model

Audience Engaged

Patient

HCP

Health system

Project Contact:

Please reach out to
lauren.w.cohen@duke.edu

for additional project information.
^‡CardioHealth Alliance (CHA) Test to Treat is a multi-sponsored effort through CHA.
CMCA Project

Determine the effectiveness of holistic, patient-centered, team-based coordinated care for cardiometabolic disease
Learn more about this initiative

Barriers the Project Aims to Address

Lack of internal support, and specialist-to-PCP transition

Aim

Determine the effectiveness of the holistic, patient-centered, and coordinated team approach to cardiometabolic disease and improve the way care is delivered to this high-risk patient population, including patients with ASCVD [Anticipated completion date: Q2 2026]^§

Strategies

Prompts/reminders

Performance dashboard

Audience Engaged

HCP

Health system

Project Contact:

Please reach out to

mmagwire@saintlukes.org
for additional project information.
^§This is a LATTICE™ Consortium expert's independent project that is sponsored by Amgen.
cvMOBIUS2

Prospective study leveraging electronic health record system to examine lipid-lowering therapy utilization and LDL-C levels
Learn more about this initiative

Barriers the Project Aims to Address

Lack of standardized metrics

Aim

Prospective registry to examine and track lipid-lowering therapy utilization and LDL-C levels in adults with ASCVD seen across 25 health systems over 5 years**

Strategies

Prospective registry

EHR data

Audience Engaged

HCP

Health system

Project Contact:

Please reach out to ann.navar@utsouthwestern.edu

for additional project information.
**cvMOBIUS2 is an Amgen-sponsored trial in collaboration with DCRI and UTSW.

cvMOBIUS2, Cardiovascular Multicenter Observational Investigation of Lipid Care in the United States-2; EHR, electronic health record.
Additional Resources:

cvMOBIUS
1 manuscript
Navar AM, Shah NP, Shrader P, Thomas LE, Ahmad Z, Allred C, Chamberlain AM, Chrischilles EA, Dhalwani N, Effron MB, Hayek S, Jones LK, Kalich B, Shapiro MD, Wójcik C, Peterson ED. Achievement of LDL-C <55 mg/dL among US adults: Findings from the cvMOBIUS2 registry. Am Heart J. 2025 Jan;279:107-117. doi: 10.1016/j.ahj.2024.06.012. Epub 2024 Jul 6. PMID: 38972336.

cvMOBIUS
2 manuscript
Shoji S, Shah NP, Shrader P, Thomas LE, Arnold JD, Dhalwani NN, Thomas NA, Kalich B, Priest EL, Syed M, Wójcik C, Peterson ED, Navar AM. Achievement of guideline-based lipid goals among very-high-risk patients with atherosclerotic cardiovascular disease and type 2 diabetes: results in 213,380 individuals from the cvMOBIUS2 registry. Am J Prev Cardiol. 2024 Dec 21;21:100921. doi: 10.1016/j.ajpc.2024.100921. PMID: 39876978; PMCID: PMC11773273.
LOGAN-CV

Evaluate a multifaceted intervention on clinician knowledge, attitudes, beliefs, and practices for guideline-based medical therapy
Learn more about this initiative

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Barriers the Project Aims to Address

Guideline changes and inconsistencies, clinician knowledge gap, clinical awareness, and poor ASCVD awareness/unintentional nonadherence

Aim

Prospective study to evaluate a multifaceted site-level intervention (performance platform and education) to enhance clinicians’ adherence to guidelines to improve LDL-C levels for patients with very high-risk ASCVD^††

Strategies

Prospective study

Education/performance dashboard

Audience Engaged

HCP

Project Contact:

Please reach out to yosef_khan@premierinc.com

for additional project information.

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LOGAN-CV

McKoy, J Nikki et al. “LOGAN-CV: A Prospective Study of a Multifaceted Intervention Targeting United States Clinicians to Improve Guideline-Based Management of Lipid-Lowering Therapy.” Advances in Therapy vol. 41,1 (2024): 451-463. doi:10.1007/s12325-023-02716-6
^††This is a collaborative study between a LATTICE™ Consortium expert and Amgen.
ACC Driving Urgency to Treat LDL‑C

Provide clinicians with tailored messages about guideline-directed medical therapy at the point of care
Learn more about this initiative

Barriers the Project Aims to Address

Limited visit time, guideline changes and inconsistencies, lack of standardized metrics, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

Aim

Build LDL-C testing and treatment awareness to action at point of care via 2018 AHA/ACC/Multisociety Guideline on the Management of Blood Cholesterol and 2022 ACC Expert Consensus Decision Pathway–based care^‡‡

Strategies

Prompts/reminders

Education

Performance dashboards

Audience Engaged

HCP

Health system

Project Contact:

Please reach out to kbyrd@acc.org

for additional project information.
^‡‡This is a LATTICE™ Consortium expert's independent project that is sponsored by Amgen.