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Ongoing Cardiometabolic Initiatives

The projects featured below are designed to improve cardiometabolic care either by demonstrating effectiveness or scaling to other
health systems.

To learn more, watch our American Journal of Managed Care (AJMC) roundtable discussion below, in which experts discuss real-world learnings and share best practices on how to start, sustain, and scale interventions for cardiovascular care.

Transforming the Management of Cardiovascular Disease at Scale:
Implementation Science in Practice

An American Journal of Managed Care Roundtable (Sponsored by Amgen)

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Up Next:

Leveraging Implementation Science: Impactful Initiatives

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Securing Stakeholder Support for Implementation Science Initiatives

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Operationalizing Implementation Science Initiatives

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Scaling and Dissemination of Implementation Science Initiatives

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Introduction to Implementation Science and LATTICETM Consortium (Video 1)

Leveraging Implementation Science: Impactful Initiatives

Experts discuss implementation of science-based LATTICE™ initiatives, including LOGAN-CV, Cardiometabolic Center Alliance, and PROMPT-LIPID, and outline the benefits of leveraging EHR systems as a support tool for launching and scaling initiatives.

Securing Stakeholder Support for Implementation Science Initiatives

Experts provide strategies and best practices for engaging important stakeholders within health systems for buy-in on implementation science initiatives.

Operationalizing Implementation Science Initiatives

Our panel discusses methods to ensure the success of implementation science initiatives, including a strong system of measurement, a strategic communication plan, and preparedness to address challenges.

Scaling and Dissemination of Implementation Science Initiatives

Implementation science experts explain approaches for scaling initiatives to more than one health system and discuss the future of LATTICE™ Consortium.

Introduction to Implementation Science and LATTICE™ Consortium

Thought leaders explain implementation science, explain how it can be applied to day-to-day clinical practice, and provide an overview of LATTICE™ Consortium.

Projects and Publications

For more information about the projects, please reach out to the corresponding author in the publication or to the project contact.

  • PROMPT-Lipid Multicenter Registry Study

    Pragmatic trial of messaging to providers about treatment of HyperLIPIDemia

    Barriers the Project Aims to Address

    Lack of quality metrics, guideline changes and inconsistencies, lack of standardized metrics, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

    Aim

    Leverage computerized decision support tools to promote guideline-concordant, high-value, quality care for patients with very high-risk ASCVD*

    Strategies

    • Prompts/reminders
    • Education

    Audience Engaged

    • HCP
    • Health system

    Project Contact:

    Please reach out to ralph.rielloiii@yale.edu

    for additional project information.

    PROMPT-Lipid

    Shah, Nimish N et al. “Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID).” American Heart Journal vol. 253 (2022): 76-85. doi:10.1016/j.ahj.2022.07.002

    *PROMPT-LIPID Multicenter Registry Study is an Amgen-sponsored study that takes the learnings from an Amgen investigator-initiated study and studies how to

    leverage these learnings at multiple sites.

  • Corrie Lipids

    Examining real-world implementation of the patient-centered Corrie Lipids program

    Barriers the Project Aims to Address

    Healthcare disparities, patient lack of knowledge of the importance of LLTs, poor ASCVD awareness/unintentional nonadherence, clinician knowledge gap, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

    Aim

    Implement a scalable and evidence-based Corrie Lipids Program (Corrie Health, Inc) to increase low-density lipoprotein cholesterol (LDL-C) awareness, treatment, and achievement of guideline-directed management

    Examine real-world implementation of the patient-centered Corrie Lipids Program guided by the implementation science framework, RE-AIM (reach, effectiveness, adoption, implementation, maintenance)

    Strategies

    • Patient-facing app
    • Clinician-focused education
    • Virtual coaching
    • Guideline-based lipid testing

    Audience Engaged

    3 integrated delivery networks (IDNs)

    Project Contact:

    Please reach out to fmarvel1@jhmi.edu

    for additional project information.

    This is a collaborative study sponsored by Amgen.

    LLTs = lipid-lowering therapies.

  • CHA Test to Treat

    Implementation of a large-scale program to identify interventions that could impact patient treatment and adherence to guideline-recommended lipid-lowering therapies

    Barriers the Project Aims to Address

    Lack of quality metrics, lack of internal support, guidelines changes and inconsistencies, clinician knowledge gap, clinical inertia, clinical awareness, continuity of care, patient lack of knowledge of the importance of LLTs, suboptimal guideline-directed medical therapy, and poor ASCVD awareness/unintentional nonadherence

    Aim

    Improve LDL-C testing and treatment planning prior to ASCVD hospital discharge and minimizing loss to follow up prior to 6 months

    Strategies

    • Prompts/reminders
    • Education
    • Navigators/care team model

    Audience Engaged

    • Patient
    • HCP
    • Health System

    Audience Engaged

    • Patient
    • HCP
    • Health System

    Strategies

    • Prompts/reminders
    • Education
    • Navigators/care team model

    Project Contact:

    Please reach out to lauren.w.cohen@duke.edu

    for additional project information.

    CardioHealth Alliance (CHA) Test to Treat is a multi-sponsored effort through CHA.

  • CMCA Project

    Determine the effectiveness of holistic, patient-centered, team-based coordinated care for cardiometabolic disease

    Barriers the Project Aims to Address

    Lack of internal support, and specialist-to-PCP transition

    Aim

    Determine the effectiveness of the holistic, patient-centered, and coordinated team approach to cardiometabolic disease and improve the way care is delivered to this high-risk patient population, including patients with ASCVD [Anticipated completion date: Q2 2026]§

    Strategies

    • Prompts/reminders
    • Performance dashboard

    Audience Engaged

    • HCP
    • Health system

    Project Contact:

    Please reach out to

    mmagwire@saintlukes.org for additional project information.

    §This is a LATTICE™ Consortium expert's independent project that is sponsored by Amgen.

  • cvMOBIUS2

    Prospective study leveraging electronic health record system to examine lipid-lowering therapy utilization and LDL-C levels

    Barriers the Project Aims to Address

    Lack of standardized metrics

    Aim

    Prospective registry to examine and track lipid-lowering therapy utilization and LDL-C levels in adults with ASCVD seen across 25 health systems over 5 years**

    Strategies

    • Prospective registry
    • EHR data

    Audience Engaged

    • HCP
    • Health system

    Project Contact:

    Please reach out to ann.navar@utsouthwestern.edu

    for additional project information.

    **cvMOBIUS2 is an Amgen-sponsored trial in collaboration with DCRI and UTSW.

    cvMOBIUS2, Cardiovascular Multicenter Observational Investigation of Lipid Care in the United States-2; EHR, electronic health record.

  • LOGAN-CV

    Evaluate a multifaceted intervention on clinician knowledge, attitudes, beliefs, and practices for guideline-based medical therapy

    Barriers the Project Aims to Address

    Guideline changes and inconsistencies, clinician knowledge gap, clinical awareness, and poor ASCVD awareness/unintentional nonadherence

    Aim

    Prospective study to evaluate a multifaceted site-level intervention (performance platform and education) to enhance clinicians’ adherence to guidelines to improve LDL-C levels for patients with very high-risk ASCVD††

    Strategies

    • Prospective study
    • Education/performance dashboard

    Audience Engaged

    • HCP

    Project Contact:

    Please reach out to yosef_khan@premierinc.com

    for additional project information.

    LOGAN-CV

    McKoy, J Nikki et al. “LOGAN-CV: A Prospective Study of a Multifaceted Intervention Targeting United States Clinicians to Improve Guideline-Based Management of Lipid-Lowering Therapy.” Advances in Therapy vol. 41,1 (2024): 451-463. doi:10.1007/s12325-023-02716-6

    ††This is a collaborative study between a LATTICE™ Consortium expert and Amgen.

  • ACC Driving Urgency to Treat LDL-C

    Provide clinicians with tailored messages about guideline-directed medical therapy at the point of care

    Barriers the Project Aims to Address

    Limited visit time, guideline changes and inconsistencies, lack of standardized metrics, clinical inertia, clinical awareness, and suboptimal guideline-directed medical therapy

    Aim

    Build LDL-C testing and treatment awareness to action at point of care via 2018 AHA/ACC/Multisociety Guideline on the Management of Blood Cholesterol and 2022 ACC Expert Consensus Decision Pathway–based care‡‡

    Audience Engaged

    • HCP
    • Health system

    Strategies

    • Prompts/reminders
    • Education
    • Performance dashboards

    Strategies

    • Prompts/reminders
    • Education
    • Performance dashboards

    Audience Engaged

    • HCP
    • Health system

    Project Contact:

    Please reach out to kbyrd@acc.org

    for additional project information.

    ‡‡This is a LATTICE™ Consortium expert's independent project that is sponsored by Amgen.

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Contact Us

Reach us at LATTICEConsortium@amgen.com to connect with peers and institutions who have track records in implementation and scaling.