This site is for U.S. Healthcare Providers only.
The projects featured below are designed to address barriers in cardiometabolic care by either demonstrating effectiveness of implementation strategies or scaling strategies to other health systems.
For more information about the projects, please reach out to the corresponding author in the publication or to the project contact.
Ongoing Initiatives
Lipid Flagging
Implementation of a lipid panel flag and EHR messaging for patients and clinicians to treat lipids based on guideline recommendations

Learn more about the FLAG LIPID study
The FLAG LIPID study will evaluate how lowered lipid panel reporting thresholds in a single health system affect cholesterol management among primary care patients. It aims to find whether these changes improve lipid-lowering therapy prescriptions, lipid levels, and provider practices, particularly in high-risk populations. This retrospective cohort study will use EMR data from 2022–2026.
Patient and clinician messaging within EHR Platform: Parallel messaging within a single health system EHR will alert patient of abnormal lipid levels.
Monitor and Addressing Gaps in Care: The lipid panel flag will prompt clinicians to follow up with patients to treat their lipids based on guideline recommendations.
Patient Activation: Patients will receive lipid panel results that flag abnormal total cholesterol, LDL-C, and triglyceride levels using lower thresholds than previously used. Clinicians will also receive messages highlighting patients’ abnormal lipid panel results to encourage patient follow-up.
Multilevel Package of Implementation Strategies to Improve LDL-C Management
Providing flexible, multilevel strategy options to close gaps in LDL-C management for high-risk cardiovascular patients

Learn more about the Cardiology Consultants of Philadelphia (CCP) Multilevel Implementation Science Study
To evaluate the effectiveness of evidence‑based, multilevel implementation strategies to improve low-density lipoprotein cholesterol (LDL‑C) testing, lipid‑lowering therapy (LLT) initiation or intensification, and achievement of guideline‑recommended LDL‑C goals among high‑risk cardiovascular patients to close the evidence-to practice gap. The study compares outcomes at 6 months post‑index visit to retrospective baseline data and assesses implementation outcomes.
Enrolled sites will deploy a clinician scorecard to provide feedback on guideline adherence
Sites will also choose other strategies they can feasibly implement such as:
Passive EHR Best Practice Alerts (BPAs) for LDL-C monitoring and treatment
Education pathways, including:
Patient + physician education with Advanced Practice Provider (APP) follow-up
HEARTWISE-ASCVD
Implementation of opportunistic AI-based coronary artery calcium screening

Learn more about the HEARTWISE-ASCVD project
Evaluate how opportunistic AI-based coronary artery calcium (CAC) screening plus notification affects lipid-lowering
therapy (LLT) and low-density lipoprotein-cholesterol (LDL-C) levels in patients with a positive CAC score, while assessing its
impact on downstream healthcare utilization patterns.
Prompts/Reminders: Notify the clinician and the patient about CAC significance using an image of calcified plaque with
recommendations for risk discussions, lipid testing, and LDL-C/LLT goals. Follow-up with the clinician and patient at month 2
if no change.
Education: Clinician facilitation and education via evidence-based treatment workflows based on ACC/AHA guidelines, ACC
Expert consensus pathways and institutional treatment guidelines.
Audit/Feedback: Provide feedback of LDL-C control via primary care reports
Motivation: Encourage patients and clinicians to act on results.
PROMPT-Lipid Multicenter Registry Study
Pragmatic trial of messaging to providers about treatment of HyperLIPIDemia

Learn more about the PROMT-LIPID Multicenter Registry
Study
Promote guideline-concordant, high value, quality care for patients with very-high risk atherosclerotic cardiovascular disease (VHR
ASCVD) by implementing the PROMPT-LIPID Toolkit across eight study sites committed to leveraging computerized decision
support (CDS) tools. Additionally, create a centralized, deidentified data repository of real-world lipid-lowering therapy (LLT)
treatment and low-density lipoprotein cholesterol (LDL-C) monitoring practices for VHR ASCVD patients to facilitate collaborative
quality improvement efforts amongst health system stakeholders.
LLT intensification at 6 months and 2 years
LDL-C goal <70 mg/dL
LDL-C goal <55 mg/dL
This is a collaborative study between a LATTICE™ Consortium Expert and Amgen.
Corrie Lipids
Examining real-world implementation of the patient-centered Corrie Lipids program

Learn more about the Corrie Lipids Program
Implement a scalable and evidence-based Corrie Lipids Program (Corrie Health, Inc) to increase low-density lipoprotein
cholesterol (LDL-C) awareness, treatment, and achievement of guideline-directed management.
Examine real-world implementation of the patient-centered Corrie Lipids Program guided by the implementation science
framework, RE-AIM (reach, effectiveness, adoption, implementation, maintenance)
Patient-facing app: Embedded clinical decision support with patient education to improve awareness of LDL-C goals along
with empowering action to adhere to lipid lowering therapies (LLT)
Clinician-focused education: Educational training session on cholesterol management defined by AHA/ACC/Multi-society
Guidelines and ACC Expert Consensus Decision Pathway
Virtual cholesterol management: Activating patients to know their LDL-C levels and engage in shared decision-making
about LLT with their clinicians
Guideline-based LDL-C testing: LDL-C is measured at baseline and repeated in 4-12 weeks if LLT is started or intensified
LDL-C test completion
LDL-C attainment at 6 months
Guideline-directed medical therapy (GDMT) LLT use
Patient activation*
*Patient activation is the process of actively involving patients in their own healthcare including shared decision-making, self-management, and partnering with HCPs
Identifying and engaging clinicians and their high-risk patients who have an indication for LLT intensification to achieve
recommended LDL-C levels
Now, speaking of things that I'm very excited about and a highlighted project from the LATTICE Consortium, I want to share my own personal experience and project that we're doing at Johns Hopkins, at Penn State and Inova and many other sites we’re interested down the road if you like.
What we wanted to do was take on the challenge of patient empowerment and engagement around LDL-C and also inspire our clinicians to learn more about the importance of guideline and recommended focused LDL-C management.
And we wanted to do that through technology because we think technology is a scalable solution that can also be delivered at many different levels of health literacy.
It's engaging, it's video focused, it's kind of our culture now to be tech forward.
And so we're excited to get started on this.
What we're doing with Corrie Lipids and if you're wondering how we came up with Corrie, Corrie means heart.
And really that's the center of what we're doing. When we came up with Corrie Lipids, we’re addressing those barriers of patients having difficulty with getting access to the right information, being unclear about what cholesterol is in LDL-C, not understanding what a heart attack is, cardiovascular disease or coronary artery disease and really finding a way where we can deliver a smartphone based engagement tool along with clinician focus education and bring those guidelines and those expert consensus statement recommendations directly to the patients and the clinician to get to goal.
What we've been looking at in terms of our outcomes is, like I mentioned, these are outcomes that we really want to focus in on.
What's the bottom line here?
Well, we've just been talking about the fact that LDL-C is the most modifiable risk factor for reducing risk of cardiovascular events.
So we wanted to focus on that and our focus was let's get the LDL-C down under 70 and ideally under 55 for secondary prevention.
But we're also including primary prevention goals as well of less than 100 for our patients.
So really let's get to those guideline and recommended goals for LDL-C because we know they're so important.
We're also looking at patient activation because, let's be honest, as clinicians at the end of the day, if we can't get our patients to buy into what we want to do with taking, helping to manage their care and inspire them, then we're not really making any forward progress.
We're doing it just to do it, but we're not really engaging the patient.
So patient activation for us was the downloading of the app, the engagement in the clinical education videos and using the Corrie application
And the kind of patients that we're engaging as I mentioned either have known ASCVD.
So these are patients who, but you might be thinking gosh, a smartphone application like perhaps you're targeting, you know, a certain younger cohort.
No, we're looking for patients who have had bypass, who have had coronary disease, stroke, have PAD are high risk, we take care of a lot of familial hypercholesterolemia patients, a lot of patients with ASCVD risk that's elevated and subclinical ASCVD and coronary calcium score and those that have statin intolerance, right. That's one of the themes that we start to educate about in our Corrie Lipids Program.
So I think when we put this together, I'll share some learnings since I think that's really important when you think about getting inspired about doing a project. You know, a lot of people were thinking to yourself, gosh, it's a busy clinical workflow.
How are you going to bring an app into the workflow for a patient?
And do you have to train them and how's this all going to work out and how are they going to engage in that?
But what we found is that there is a interest from the patients to learn more that we often can't cover in a very short clinical exchange in our clinics, right?
We have maybe 15-30 minutes if you're lucky with the patient.
And so we learned that, yes, there are some always technical challenges that come with letting someone know that they're going to be downloading an app and they're going to start to use it.
But we're trying to tackle a problem that hasn't been tackled before.
And we're working with our nurses, with our leadership who were very quick to say we're interested. We're interested in trying to do something that's patient centered that could ultimately deliver better guideline based care.
And you're doing this in a programmatic fashion that's systematic, that's using the re-aim framework, which helps us to explore an implementation model about, is this going to work, at our clinics, but is this also going to work at our other sites?
And can we get up to 1000 patients rapidly to use this tool? And then ultimately, is it going to make a difference?
And so I, I just want to share those kinds of learnings and conversations and points because, I sure don't want to get up here and make you think, gosh, okay, they did it there, but it might be challenging to do it at, our center.
There might be challenges, but all of those challenges can be overcome with starting to work with the right stakeholders, having good collaborative conversations and just never giving up when it comes to getting LDL-C under better control.
So that's some of our experiences with Corrie Lipids. I'll mention one more thing.
We are already getting early data and I can't share that in this presentation, but I'm hoping that next year we can start to give you a glimpse at how this is making a difference with our patients engaging our LDL-C numbers.
And it's just hopefully an inspiration to all to think, gosh, you know, it's one thing to create ABPA, it's one thing to do an educational, but going in and really doing an intervention that's like a smartphone app that, you know, those are next level kind of things.
I encourage you all to be next level to think about how this can be really great for your institution, whether you choose technology or whether you choose a paper based program or whether you choose to do something totally separate from the EHR.
But go ahead and take the challenge because at the end of the day, we're already seeing great results on our side.
And it took a lot to get it started.
But now that we're moving, it's so exciting to see the difference and to also see our patients really resonate.
CHA Test to Treat
Implementation of a large-scale program to identify interventions that could impact patient treatment and adherence to
guideline-recommended lipid-lowering therapies

Learn more about the CHA Test to Treat Project
Implementation of a large-scale program to identify interventions that could impact patient treatment and adherence to
guideline-recommended lipid-lowering therapies (LLT). The program gathers data to identify how to improve quality of care
during hospitalization and through six months post-discharge among patients hospitalized for myocardial infraction (MI) or
percutaneous coronary intervention (PCI).
Inpatient intervention: Increase low-density lipoprotein cholesterol (LDL-C) testing and identification of evidence-based LLT
as appropriate before discharge
Outpatient intervention: Increase repeat LDL-C testing; Identification of evidence-based LLT as appropriate to reach
recommended LDL-C thresholds (registered nurse remotely coordinates care to help ensure repeat LDL-C
testing and LLT adherence)
Increase LDL-C testing rates
Improve GDMT
Improve outpatient follow-up rates
Increase achievement of LDL-C recommended levels
For sites/systems to be eligible for project participation, they must be a member of the CardioHealth Alliance
This is a LATTICE™ Consortium expert’s independent project that is sponsored by Amgen.
Completed Initiatives
LOGAN-CV
Evaluate a multifaceted intervention on clinician knowledge, attitudes, beliefs, and practices for guideline-based medical therapy

Learn more about the LOGAN-CV project
Evaluate the impact of a multifaceted intervention – consisting of a performance dashboard, clinician education modules,
patient engagement materials, monthly newsletters, and live peer-to-peer discussion calls – on clinician knowledge-
attitudes-beliefs (KAB) and practices as compared to guideline recommendations for adult patients with recent myocardial
infarction (MI) and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL on a statin.
Equip clinicians with multifaceted tools to help improve adherence to guideline-based recommendations
Education modules and peer-to-peer discussion calls
Online performance platform dashboard with a tailored summary of the patients’ lipid management
Results during the 1 year intervention, for 2 completed sites, including 15 clinicians and 126 patients:
Practices may be eligible to use the Premier Performance Dashboard if they are part of the Premier Network
ACC Driving Urgency to Treat LDL-C
Provide clinicians with tailored messages about guideline-directed medical therapy at the point of care

Learn more about the ACC Driving Urgency Project
Increase the rate of diagnostic screening of low-density lipoprotein cholesterol (LDL-C) in patients with and
without ASCVD to improve awareness and implementation of 2018 Guidelines on the Management of Blood
Cholesterol, and 2022 ACC Expert Consensus Decision Pathway (ECDP) at a national scale.
Equip cardiology and primary care clinics to deploy GDMT-related awareness communications and practice/patient-level
ASCVD dashboards using:
Veradigm Practice Fusion EHR system, a cloud-based EHR platform that provides reliable, secure access to information
Veradigm TouchPoint Media solution, a tool to reach targeted providers at the point-of-care
HealthPALS CLINT MAX system, an artificial intelligence platform to analyze patient data and identify actionable care gaps
Clinician engagement (message impressions, click through rates, dashboard sign-up, dashboard usage)
Improvements in lipid testing
Lipid treatment in patients with hypercholesterolemia and ASCVD patients
Practice eligibility for project based on:
EHR = electronic health record; GDMT = guideline-directed medical therapy
1. Data on file, Amgen; 2022. 2. Shah NN, et al. American Heart Journal. 2022;253:76-85. 3. Magnussen, et al. N Eng J Med. 2023;389(14):1273-85. 4. American Heart Association. My LDL-C Cholesterol Guide. www.heart.org. Accessed August 15, 2025. 5. Heart Disease Risk Factors. www.cdc.gov. Accessed August 15, 2025.
This is a LATTICE™ Consortium member’s independent project that is sponsored by Amgen.
Primary Care Assist
Determine the effectiveness of holistic, patient-centered, team-based coordinated care for cardiometabolic disease

Learn more about the CMCA Project
Determine the effectiveness of the holistic, patient-centered, team-based care coordinated approach to cardiometabolic disease and improve the way care is delivered to this high-risk patient population including patients with ASCVD at four key practice settings across the U.S. Advanced practice providers (APPs) and pharmacists (PharmDs) are extenders of care that can support the primary care provider (PCP) care for patients.
Equip APPs or PharmDs to champion CMCA protocols and care model embedded within primary care
Involvement in the Cardiometabolic Center AllianceTM
LDL tests ordered
LDL tests completed
Repeat LDL tests
Average LDL trend
Percent of patients that achieve LDL target
cvMOBIUS2
Prospective study leveraging electronic health record system to examine lipid-lowering therapy utilization and LDL-C levels

Learn more about the cvMOBIUS2 project
Examine and track lipid-lowering therapy (LLT) utilization and low-density lipoprotein cholesterol (LDL-C) levels in adults
with atherosclerotic cardiovascular disease (ASCVD) seen across a maximum of 25 health systems over 5 years. Annual sub-
analysis will evaluate factors associated with achievement of appropriate LDL-C lowering in various cohorts of adults with
ASCVD.
Prospective registry study leveraging Patient-Centered Clinical Research Network (PCORNET) electronic health record
(EHR) system to examine LLT utilization and LDL-C levels
Increase proportion of patients with ASCVD that are identified and, where appropriate, treated according to ACC/AHA
guideline recommendations for LLT
Understand baseline characteristics of people with established ASCVD who initiate non-statin LLTs versus those who
don’t initiate non-statin LLTs
Improve clinical outcomes in adults by LDL-C level at baseline and over time
Understand health system heterogeneity of utilization of non-statin LLTs
Track lipid trajectories in patients with ASCVD by treatment status
Recognize novel patterns in LLT uptake
This is a collaborative study between a LATTICE™ Consortium Expert and Amgen.
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Reach us at LATTICEConsortium@amgen.com
to connect with peers and institutions who have
track records in implementation and scaling.